The Rise and Fall of Antibiotics

Over the past 90 years, antibacterial discovery has gone from boom to bust. For about 30 years in the middle of the 20th century, pharmaceutical companies regularly developed new classes of the drugs, many of which doctors still use today, such as penicillin and the tetracyclines. However, by the 1980's, discovery slowed and companies started leaving the field, drawn by the rise of profitable drugs in other therapeutic areas. As a result, only one successful new class of antibacterial drugs has been discovered since the late 1980's (bedaquiline). This is the story of the Rise and Fall of Antibiotics.



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